中文摘要：

目的：观察IDl对大鼠胶质瘤细胞（c6细胞）侵袭转移能力的影响。方法：以C6细胞为研究对象，ID1 siRNA通过脂质体转染c6细胞，western blot检测C6细胞中ID1、P-NF—KBp65蛋白的表达、Elisa法检测细胞培养上清MMP．9的含量，Transwell小室观察成的转移侵袭能力。结果：干扰ID1后能显著降低C6细胞中P-NF-KBp65蛋白、细胞培养上清中MMP-9的含量（P〈0．01），降低C6细胞的转移侵袭能力（P〈0．01）。结论：干扰ID1能抑制C6细胞的转移侵袭，其机制可能与抑制C6细胞中P-NF-K Bp65蛋白、MMP-9的表达有关。

英文摘要：

Objective： To study the effect of ID 1 on invasive ability of C6. Methods： C6 cells were divide into control, non sense, ID1 siRNA groups. The effects of IDlsiRNA on C6 cells invasive ability in vitro was measured by Boyden chamber invasive models. Contents of ID1, NF-K Bp65, MMP-9 protein were detected by western blot and ELISA methods, respectively. Result： In ID1 siRNA group, contents ofNF-K Bp65 and MMP-9 protein were decreased markedly（P〈0.01）, the invasive ability was decreased markedly（P〈0. 01）, too. Conclusion： IDI could increase the invasive ability of C6 cell.