中文摘要：

目的 探讨急性心肌梗死（AMI）患者入院时和1年后血清网膜素-1水平变化及其可能的意义.方法 试验组连续纳入2013年3月至2014年9月AMI发作12 h内于首都医科大学附属北京安贞医院就诊患者共90例.对照组选取与试验组年龄和性别匹配,于首都医科大学附属北京安贞医院体检的健康受试者30人.采用ELISA法检测所有对象入院时血清网膜素-1水平.结果 试验组中ST段抬高性心肌梗死（STEMI）占67.8％,非ST段抬高性心肌梗死（NSTEMI）占32.2％.急诊或择期血运重建共91.1％,住院期间死亡4例,随访期间死亡3例,失访6例.试验组较对照组参试者入院时基线血清网膜素-1水平显著降低（P＜0.05）,试验组对象随访1年时血清网膜素-1较基线水平明显升高（P＜0.05）.试验组中与血清网膜素-1显著相关的因素包括：体重指数（BMI）（r=-0.36,P=0.026）、肌钙蛋白Ⅰ（cTnⅠ）（r=-0.28,P=0.043）、稳态胰岛素评价指数（HOMA-IR）（r=-0.32,P=0.041）和高敏C反应蛋白（hs-CRP）（r=-0.65,P=0.038）.多因素分析中,仅入院时和1年时hs-CRP水平（β=-0.34,P=0.036;β=-0.56,P=0.001）与血清网膜素-1水平呈独立负相关.结论 AMI患者较健康人血清网膜素-1基线水平明显降低,而AMI患者随访1年时血清网膜素-1较基线水平明显升高,同时血清网膜素-1和炎症水平变化密切相关.

英文摘要：

Objective： To investigate the change patterns and underlying meaning of serum omentin-1 levels in patients occurred acute myocardial infarction （AMI）. Methods： Ninety patients experiencing AMI were consecutively enrolled from March 2013 to September 2014 （AMI group）. Thirty age- and sex-match healthy individuals were enrolled as control group. ELISA was used to measure serum omentin-1 levels in all participants. Results： In AMI group, patients encountered STEMI and NSTEMI were 67.8% and 32.2%, respectively. And 91% patients underwent primary or elective revascularization, as a result, 4 patients were death in hospital and 3 during follow-up, another 6 patients were lost to follow-up. Serum omentin-1 levels were lower in AMI group than control group at baseline （P＜0.05）, and serum omentin-1 levels were higher in AMI group at 1 year after discharge than baseline （P＜0.05）. The parameters significantly correlated with serum omentin-1 levels in patients with AMI were BMI （r=-0.36, P=0.026）, cTnI（r=-0.28, P=0.043）, HOMA-IR（r=-0.32, P=0.041） and hsCRP（r=-0.65, P=0.038）. In the multivariate analysis, only hsCRP on admission and at 1 year （β=-0.34，P=0.036；β=-0.56，P=0.001）were independently and reversely associated with serum omentin-1 levels. Conclusion： Serum omentin-1 levels were lower at baseline in patients with AMI, and increased at 1 year follow-up, in addition, serum omentin-1 levels were significantly correlated with hsCRP levels.