中文摘要：

鞘磷脂代谢产物在细胞中具有重要的生理学意义。其代谢产物中神经酰胺和鞘氨醇具有抑制细胞生长、促进细胞凋亡的作用。而1-磷酸鞘氨醇（S1P）则具有促进细胞增殖、分化的作用。鞘磷脂代谢产物的动态平衡决定着细胞的生存和死亡。据此有人提出了“鞘磷脂变阻器”的概念。深入探讨鞘磷脂代谢产物．不但能从分子层面去更多了解细胞的生存机制，而且能为临床提供疾病治疗的新靶点。

英文摘要：

Sphingomyelin metabolites in the cells has important physiology meaning.The metabolites of ceramide and sphingosine inhibition of cell growth,and promote the role of cell apoptosis.And the role of S1P has promote cell prolif- eration,and differentiation.The dynamic balance of sphingomyelin metabolites determines cell of survival and death.So, someone accordingly puts forward the concept of ＂sphingomyelin rheostat＂.Explore sphingomyelin metabolic product, not only from the molecular level to learn more about survival mechanism of cells,and can provide us with novel tar- gets for therapeutic disease.