中文摘要：

目的探讨异丙酚对哮喘大鼠骨形态构建蛋白4（BMP-4）表达的影响。方法SD大鼠45只，随机分为3组，对照组（Ⅰ组）15只，为健康大鼠；哮喘模型组（Ⅱ组）15只，为卵清白蛋白（OVA）致敏后吸入激发建立模型；异丙酚组（Ⅲ组）15只，为哮喘大鼠给予异丙酚50mg·kg^-1·h^-1，2h。用HE染色后病理图像分析方法检测大鼠气道形态学参数，免疫组化方法检测BMP-4表达定位，Western蛋白印迹法测定BMP-4含量。结果Ⅱ组与Ⅰ组相比，支气管内径缩小，平滑肌层增厚，BMP-4含量减少7。9％（P〈0．05）；Ⅲ组与Ⅱ组相比，支气管内径有所增大，肺内含有BMP-4含量增加4．1％（P〈0．05）。结论异丙酚对哮喘大鼠肺内BMP-4表达降低趋势有所缓解，可能是其气道保护作用机制之一。

英文摘要：

Objective To investigate the effect of propofol on the expression of BMP-4 in the lung of asthma rat model. Methods Fortyfive SD rats were randomly divided into three groups,15 for each group：group Ⅰ ,healthy rats as control group; group Ⅱ ,asthma group where a asthma rat model was established by sensitization and challenge with ovalbumin （OVA） ; group HI, propofol group, propofol 50 mg· kg^-1· h^-1 was continuously infused iv for 2 hours after the same treatment as group Ⅱ .The change of airways and the expression of BMP-4 were determined by image analysis system,immunohistochemistry and Western blotting. Results BMP-4 was found on the bronchial epithelium,in the vascular endothelium,and on a few scattered alveolar cells of all groups. There were a decline in A1/D and an increase in A2/D in the airways of group Ⅱ as compared with those of group Ⅰ （P 〈 0.05 ）. The BMP-4 level in group Ⅱ was lower than that of group Ⅰ （P 〈 0.05）. The level of A1/D was higher in group Ⅲ compared with that of group Ⅱ and the level of BMP-4 also increased 4.1%（P 〈 0.05）. Conclusion The expression of BMP-4 decreases in the asthma rat model. Propofol attenuates the decrease, which may be one of the mech- anisms of airway protection of propofol.