中文摘要：

Autophagy 是一高度调整了并且 multistep 由此的生物过程房间在下面新陈代谢， proteotoxic，或另外的压力由 shuttling 移开不正常的细胞器或 misfolded/polyubiquitinated 蛋白质他们经由为降级称为 autophagosomes 到 lysosome 的专业化结构。尽管 autophagy 通常被认为是一个非选择的过程，积累的证据建议它能有选择地也降级特定的目标货物。这些选择目标包括蛋白质，线粒体，和平入侵细菌。autophagic 改编者的发现和描述，例如 p62/Sequestosome 1 (SQSTM1 ) 并且 BRCA1 基因 1 的邻居(NBR1 ) ，提供了机械学的卓见进选择 autophagy。这些受体都能为 ubiquitinated 底层的降级充当货物受体。这评论主要关于在调整选择 autophagy 起重要作用的关键受体蛋白质总结最新的调查结果。

英文摘要：

Autophagy is a highly regulated and multistep biological process whereby cells under metabolic, proteotoxic, or other stresses remove dysfunctional organelles and/or misfolded/polyubiquitinated proteins by shuttling them via specialized structures called autophagosomes to the lysosome for degradation. Although autophagy is generally considered to be a non-selective process, accumulat- ing evidence suggests that it can also selectively degrade specific target cargoes. These selective targets include proteins, mitochondria, and even invading bacteria. The discovery and characteriza- tion of autophagic adapters, such as p62/Sequestosome 1 （SQSTM1） and Neighbor of BRCA1 gene 1 （NBR1）, have provided mechanistic insights into selective autophagy. These receptors are all able to act as cargo receptors for the degradation of ubiquitinated substrates. This review mainly sum- marizes the most up-to-date findings regarding the key receptor proteins that play important roles in regulating selective autophagy.