中文摘要：

目的：评估SPECT测定不同年龄段健康人肾小球滤过率（GFR）的准确性。方法：以232例北京地区社区健康居民为研究对象，分别采用双血浆法和99Tcm-二亚乙基三胺五乙酸（99Tcm-DTPA）肾动态显像法测定肾GFR（GFRdt和GFRGates）。以GFRdt为参照标准，分析比较SPECT测定20～29岁、30～39岁、40～49岁、50～59岁、60～69岁及〉70岁的6个不同年龄组健康人肾小球率过滤的准确性。结果：①6个不同年龄组所得GFRGat6es与GFRdt均具有显著性差异。②6个不同年龄组所得GFRGates均明显低于GFRdf，其中30～39岁年龄段GFRGates与GFRdt的差异最大，差异均值为（-34．26±20．79）；〉70岁年龄组GFRGates与GFRdt的差异最小，差异均值为（-9．48±10．85）。③30～39岁组GFRGates与GFRdt相关性（r=0．42）最差；〉70岁组GFRG№与GFRdt相关性（r=0．81）最好。结论：SPECT~]定20～49岁健康人GFR的准确性较差，测定≥50岁健康人GFR的准确性较好，其中≥70组准确性最好。

英文摘要：

Objective： To estimate the accuracy of SPECT determination glomerular filtration rate in different age healthy groups. Methods： Totally 232 Beijingcommunity health residents were selected as the research subjects. Two-sample method and ＂Tc＇＂-DTPA dynamic renal imaging were usea Ior determination of GFR （GFRdt and GFR6ates, respectively）. GFRdt as the reference standard, compare the accuracy of six different age groups GFR~ate~ which get by SPECT. Results： ~There were significant differences between GFRdt and GFRGat~ on six different age groups. ~GFRG,,~ from Six different age groups were significantly lower than those of GFRdt. The difference in the group of 50-59years between GFRdt and GFRGat~ is maximum, the mean difference is （-54.26_-_20.79） ml/（mino 1.75m）2. The difference in the group of _〉70years between GFRat and GFR6ates is minimum, the mean difference is （-25.62_＋ 18.60） ml/（min＊ 1.75m）2. ~GFRdt and GFR6,tes derived from the group 50-39years had the worst correlation （r=0.42）. GFRdt and GFR~ate~ derived from the group -~70years had the best correlation （r=0.81）. Conclusion： The accuracy of GFR which got by SPECT is poor in 20-49years health group, it is better in _〉50 Years health group, while it is the best in 〉-70 years health group.