中文摘要：

利用太赫兹时域光谱技术（THz-TDs）对D-、L-和DL-青霉胺的研究发现，三种样品在0．2THz到1．8THz波段的吸收光谱存在显著差异，实验结果表明，THz吸收光谱能够鉴别青霉胺对映异构体，这一特点将可以用于青霉胺药物的检测．本文利用纯D-、L-青霉胺的THz吸收光谱，对D-、L-青霉胺混合样品的THz吸收光谱进行拟合，证明可以用THz光谱定量分析混合样品中D-,L-青霉胺的相对含量．这项研究为手性药物分子检测和分析提供了新的实验方法，也对深入了解手性药物与生物靶分子之间相互作用提供了启示．

英文摘要：

Far-infrared absorption spectra of D-, L-, and DL- penicillamines have been measured by terahertz timedomain spectroscopy （THz-TDS） in the frequency range from 0.2 THz to 1.8 THz. The experimental results show large difference among absorption spectra of enantiomers （D- and L- peniciUamines） and their racemic compound （DL- penicillamine）, which probably originated from the difference of crystal structure and vibration modes of crystal lattice. The study indicates that THz-TDS can be used for discrimination of D-, L-, and DL- peniciUamines. The absorption spectra of their mixtures have been fitted by the absorption spectra of D- and L- penicillamines, and we have demonstrated the feasibility of this method to determine quantitatively the mixture ratios of penicillamine enantiomers. These will not only give a new experimental method to distinguish chiral medicine, but also provide a suggestion for further comprehending the interaction of chiral medicine and target biomolecule.