中文摘要：

目的初步探讨生物可吸收性形状记忆聚合物（biodegradable shape-memory polymer,BSMP）的生物相容性。方法体外试验：将鼠胚胎成纤维细胞与BSMP共培养,观察细胞形态特征,并通过MTT检测评价BSMP的体外生物相容性。体内实验：将BSMP植入新西兰兔皮下与肌肉内,术后不同时间点观察局部与宏观表现后取材送组织学检查,并检测材料埋入肌肉后的重量丢失百分比,综合评价BSMP的体内生物相容性。结果与BSMP共培养的BSMP组鼠胚胎成纤维细胞与未与BSMP共培养的对照组相比,生长状态良好,MTT检测无明显差异（P〉0.05）;皮内植入BSMP24、48、72h后BSMP组及对照组手术部位均未发现红斑或水肿,皮内刺激检测的评分是0,且BSMP植入皮内后的第2周及第4周BSMP组及对照组的组织学观察没有发现明显的栓塞、水肿、坏死及炎性介质反应;BSMP植入肌肉后24周的降解总量达8.4%。结论 BSMP生物相容性良好,体内降解速率稳定,是一种良好的聚合材料。

英文摘要：

Objective To explore the biocompatibility of the biodegradable shape-memory polymer （BSMP）. Methods In vitro experiment： the mouse embryonic fibroblast cells were cultivated with BSMP. Microscopic characteristics of cells were observed through invertedmicroscope. MTT method was applied to observe and analyze the in-vitro biocompatibility of BSMP. In vivo experiment ： BSMP was embedded into the skin and muscles of New Zealand rabbit, specimen local and macro performances were observed in different time points after surgery, then histological detection was carried out. The sample weight loss percentage was measured after muscle implantation and synthetically to evaluate the in-vivo biocompatibility of BSMP. Results Compared with the control group, mouse embryonic fibroblast cells with BSMP showed good growth state, no obvious difference was found by MTF test （P 〉 0.05 ）. Erythema or edema were not found in surgery spot of BSMP group and control group in 24 h, 48 h, 72 h after intradermal implant with BSMP. Skin stimulation test score was zero and embolism, swelling, corrosion or ulcers were not found in subcutaneous tissues of BSMP group and control group in 2 and 4 weeks after intradermal implant with BSMP. The total degradation of 24 weeks was 8.4% after BSMP implanted in muscle. Conchmion BSMP in the in-vivo and in-vitro experiments had demonstrated good biocompatibility and had a steady degradation rate. So BSMP is a very good polymermaterial.