中文摘要：

以取代靛红和肌氨酸为原料制得1,3-偶极子,再与（E）-芳姜烯酮类化合物在乙腈中经3＋2环加成反应合成了10个新型的芳姜黄酮拼合吡咯螺环氧化吲哚类化合物（3a~3j）,产率70%~91%,d/r值15∶1~〉20∶1,其结构经~1H NMR,~（13）C NMR和HR-MS（ESI-TOF）表征。采用MTT法研究了3a~3j对人肺癌细胞（A549）和人白血病细胞（K562）的体外抗肿瘤活性。结果表明：3f对K562抑制活性较好（IC50=31.1μmol·L-1）,3b对A549抑制活性较好（IC50=54.1μmol·L~（-1））。

英文摘要：

Ten novel turmerone motif-fused spiropyrrolidine oxindoles（3a~3j） were synthesized by 1, 3-dipolar reaction of substituted isatins with sarcosine, then 3＋2 cycloaddition with （ E）-dienones in MeCN.The yields and d/r of 3a~3j were 70%~91%and 15∶1~〉20∶1, respectively.The struc-tures were characterized by 1 H NMR, 13 C NMR and HR-MS（ ESI-TOF） .The in vitro antitumor activi-ties against human lung cancer cells（A549） and human leukemia cells（K562） were demonstrated by MTT assays.The results showed that 3f exhibited best activity against K562 with IC50 of 31.1 μmol· L-1 and 3b indicated best activity against A549 with IC50 of 54.1 μmol· L-1 .