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中文摘要：
用紫外-可见光谱（UV-Vis spectroscopy）表征载有布洛芬（ibuprofen）和吡罗昔康（piroxicam）复方药物的聚甲基丙烯酸甲酯（PMMA）膜在磷酸盐缓冲溶液（PBS）中的释放过程，观察两种药物在时间外扰下的释放情况．随着时间的推移，两种药物都保持了持久的释放．同时，通过二维紫外相关光谱（two-dimensional UV correlation spectroscopy）来进一步探究两种药物从PMMA膜内释放到缓冲溶液中的先后顺序，推断出布洛芬与PMMA之间形成了一定的氢键相互作用，导致释放速度变缓．复方载药膜的红外光谱证明了这种相互作用的存在，验证了二维紫外相关光谱在药物缓释领域的潜在应用价值．
英文摘要：
UV-Vis spectroscopy was utilized to monitor the release process of ibuprofen and piroxicam from PMMA film in the phosphate-buffered saline （PBS）. Both of the drugs maintained a continuous release process under time perturbation. Furthermore, two-dimensional UV correlation spectroscopy was applied to explore the sequence of the drug release and it was implied that hydrogen-bonding interaction was formed between ibuprofen and poly （methyl methacrylate （PMMA）, which was responsible for the lower speed of release. FTIR spectra of drug-containing PMMA film confirmed the existence of the interaction and the potential applications of two-dimensional UV correlation soectroscoov in drug release have been confirmed.
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