中文摘要：

自噬是一种溶酶体依赖性的大分子蛋白质和细胞器降解过程,通过清除衰老的细胞器和长寿命蛋白质,为细胞修复提供原料与营养,实现细胞器更新。自噬现象几乎存在于所有真核细胞内,在细胞生长、增生以及死亡等过程中发挥着重要作用。近年来,自噬作为生物学领域里的一个新的研究热点,在肾脏疾病领域被越来越广泛的研究。在某些条件下,自噬可以起到保护肾脏的作用,但处于另外一些情况时,自噬则可以导致肾脏固有细胞的损伤,进而引发多种肾脏疾病。近年来国内外研究发现多种中药有效成分可以调节细胞自噬,细胞自噬在中医药领域得到广泛研究。文章旨在对自噬及其在肾脏疾病领域中的研究进展作一综述,为自噬在肾脏疾病领域中的更深入研究提供参考。

英文摘要：

Autophagy is a degradation process of lysosomal-dependent macromolecular proteins and organelles,which provides raw materials and nutrition for cytothesis and renewal of organelle by clearing senescent cells and long-lived proteins.Autophagy occurs in almost all eukaryotic cells playing an important role in the growth,proliferation and death of cells.In recent years,as a new research hotspot in the field of biology,autophagy has been studied with wider scopes in the field of kidney disease.Under certain conditions,autophagy may play a protective role in the kidney,but in other cases,autophagy could lead to injury to innate renal cells,triggering a variety of kidney diseases.In recent years,studies home and abroad have found many active components of traditional Chinese medicine can regulate autophagy.This paper reviews the researches on autophagy and autophagy in kidney disease to provide references for further researches in the field of kidney disease.