中文摘要：

为了研究对乙酰氨基酚和乙酰半胱氨酸单用或联用后对仔猪氧化应激的影响，试验采用脂多糖诱导（按体重100μg／kg进行腹腔注射）的方法建立仔猪氧化应激模型，检测药物对血浆中总抗氧化能力（T—AOC）、超氧化物歧化酶（SOD）、丙二醛（MDA）、还原型谷胱甘肽（GSH）和谷胱甘肽过氧化物酶（GSH—Px）等抗氧化指标的影响。结果表明：对乙酰氨基酚（混饲600mg／kg）和乙酰半胱氨酸（混饲1200mg／kg）单用或联用，对健康仔猪血浆中抗氧化能力指标无明显影响；脂多糖诱导后3小时仔猪血浆中MDA含量显著升高（P〈0．05），SOD活性和GSH含量显著降低（P〈0．05）；对乙酰氨基酚单用可抑制SOD含量的降低（P〈0．05），乙酰半胱氨酸单用、乙酰半胱氨酸与对乙酰氨基酚联用对脂多糖诱导的血浆中MDA含量、SOD活性和GSH含量的异常变化具有显著的缓解作用（P〈0．05）；脂多糖诱导后24小时，各处理组仔猪血浆中抗氧化指标均恢复正常水平。

英文摘要：

To study the effects of acetaminophen and acetylcysteine administered alone or in combination on oxidative stress in piglets, the oxida- tive stress models in piglets were established by the lipopolysaccharide （LPS） induction （100 μg/kg · bw, ip）, for determining the effects of these drugs on some antioxidant indicators in plasma, such as total antioxidant capacity （T- AOC）, superoxide dismutase （SOD）, malondial- dehyde （ MDA）, reduced glutathione （ GSH ）, glutathione peroxidase （ GSH - Px）, and other antioxidant indicators. The resuh showed that paracetamol （600 mg/kg in basal diet） and acetylcysteine （1 200 mg/kg in basal diet） administered alone or in combination had no effects on plasma antioxidant capacity in healthy piglets. After 3 h of LPS induction, the content of MDA was significantly increased （ P 〈 0.05 ） in the plasma of the piglets , while SOD activity and GSH content were significantly decreased（ P 〈 0.05） in the plasma. Pamcetmnol administered a- lone could inhibit the decrease of SOD activity（ P 〈 0.05 ）. Acetylcysteine alone or in combination with paracetamol could significantly alleviate （ P 〈 0.05 ） abnormal changes in the content of MDA , SOD activity, and GSH content in the plasma induced by LPS. However, these antioxi- dant indicators returned to normal levels in the piglet plasma from the treatment groups after 24 h of LPS induction.