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Au nanoclusters suppress chronic lymphocytic leukaemia cells by inhibiting thioredoxin reductase 1 to induce intracellular oxidative stress and apoptosis

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分类：Q51[生物学—生物化学] S858.315.3[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
作者机构：[1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China, [2]University of Chinese Academy of Sciences, Beijing 100049, China, [3]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China, [4]Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China, [5]Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
相关基金：This work was supported by the National Key Basic Research Program of China （2013CB932703）, the National Natural Science Foundation of China （21425522, 81472851, 31670976, 21390410, 31571026, 31500815, 51571185, and 21675157） and Beijing Natu- ral Science Foundation （7152158）.

作者： Qiong Li[1,3], Qing Yuan[2,3,4], Mohan Zhao[5], Yawen Yao[4], Liang Gao[3], Ru Liu[3], Yaling Wang[3], Yong Gong[5], Fuping Gao[3], Xueyun Cao[3,4]

关键词：硫氧还蛋白还原酶, 淋巴细胞白血病, 细胞内, 氧化应激, 细胞凋亡, 金纳米簇, 慢性, 诱导, Chronic lymphocytic leukaemia （CLL）, Gold nanoclusters, Thioredoxin reductase （TrxR）, Mitochondrial membrane potential （MMP）, Apoptosis

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