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Pleiotropic Effects of Herbs Characterized with Blood-Activating and Stasis-Resolving Functions on Angiogenesis

ISSN号：1000-7431
期刊名称：《肿瘤》
时间：0
分类：Q782[生物学—分子生物学] TS972.122[轻工技术与工程]
作者机构：[1]Jiangsu Key Laboratory for Pharmacology and SafetyEvaluation of Chinese Materia Medica, School of Pharmacy,Nanjing University of Chinese Medicine, Nanjing (210023), China, [2]Jiangsu Collaborative Innovation Center of Traditional ChineseMedicine Prevention and Treatment of Tumor, Nanjing Universityof Chinese Medicine, Nanjing (210023), China, [3]Department of Pharmacy, Provincial Hospital Affiliated to Anhui MedicalUniversity, Hefei (230001), China, [4]Fujian Provincial Hospital,Clinical College of Fujian'Medicai University, Fuzhou (350001),China, [5]Department of Pharmacology, Hanlin College,Nanjing University of Chinese Medicine, Taizhou Jiangsu Province (225300), China, [6]Department of Pharmaceutics,Jinling Hospital, Nanjing University School of Medicine, Nanjing(210002), China
相关基金：Supported by the National Natural Science Foundation of China （Nos. 81173174, 81403260 and 81573859）, China Post-doctoral Science Foundation （No. 2014M551639）, Natural Science Foundation of Jiangsu Province （No. BK2012854）, Postdoctoral Funding in Jiangsu Province （No. 1401138C）, 2013 Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education （No. PPZY2015A070）, the Priority Academic Program Development of Jiangsu Higher Education Institutions, and Jiangsu College Graduate Research and Innovation Proiects （No. CXZZ13_0627）

作者：陶丽[1], 王生[1], 赵杨[1], 王爱云[1,2], 张蕾[3], 阮君山[4], 范方田[5], 刘玉萍[1], 李尧[1], 岳志强[1], 钱文慧[6], 陈文星[1,2], 陆茵[1,2]

关键词：肿瘤血管生成, 活血化瘀, 中药, 多效性, 缺血性疾病, 相互作用, 静止状态, 基础环, blood activating and stasis resolving, Chinese medicine, pro-angiogenesis, anti-angiogenesis,physiological angiogenesis, pathological angiogenesis, arteriogenesis

中文摘要：

Accumulative evidences have underpinned the nature candidates from Chinese medicine(CM), particularly CM served as blood activating and stasis resolving(BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that(1) BASR-CM might emphasize on a balanced multi-cytokines network interaction;(2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis;(3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.

英文摘要：

Accumulative evidences have underpinned the nature candidates from Chinese medicine （CM）, particularly CM served as blood activating and stasis resolving （BASR, Huoxue Huayu in Chinese） by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that （1） BASR-CM might emphasize on a balanced multi-cytokines network interaction; （2） BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; （3） BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.

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