中文摘要：

目的 分析太原市和长治市空气中多环芳烃的含量和新生儿神经行为发育检查（NBNA）得分,探讨孕妇呼吸含多环芳烃的空气对新生儿神经行为发育的影响.方法 应用高效液相色谱法测定2009年11月至2010年5月长治市和太原市合作医院空气中多环芳烃含量、同期在合作医院生产的297名孕妇的尿中1-羟基芘含量,应用NBNA法测定新生儿神经行为发育情况,对两地空气中多环芳烃含量、孕妇尿中1-羟基芘含量和NBNA得分进行比较.结果 太原市和长治市空气中芘、苯并[a]蒽、屈、苯并[a]芘、二苯并蒽含量的差异有统计学意义（P＜0.10）.太原合作医院孕妇的尿中1-羟基芘含量中位数为1.140 μg/mmol Cr（P5为0.457 μg/mmol Cr,P75为2.678 μg/mmol Cr）,长治合作医院孕妇的尿中1-羟基芘含量中位数为0.761 μg/mmol Cr（P25为0.133 μg/mmol Cr,P75为2.095 μg/mmol Cr）,两地合作医院孕妇尿中1-羟基芘含量的差异有统计学意义（t=-3.140,P=0.002）.太原市和长治市新生儿NBNA总分、行为能力得分、被动肌张力得分、主动肌张力得分和一般估价得分比较,差异有统计学意义（P＜0.10）.NBNA得分及单项得分与孕妇尿中1-羟基芘含量有负相关关系.结论 妇女孕期呼吸含多环芳烃的空气对新生儿神经行为发育有不良影响.

英文摘要：

Objective To compare the difference of polycyclic aromatic hydrocarbons（PAHs）levels in the urban air and the scores of Neonatal Behavioral Neurological Assessment（NBNA）between Taiyuan and Changzhi cities and to explore the effects of PAHs in the urban air during pregnancy on neonatal behavioral neurological development.Methods High-performance liquid chromatography（HPLC）with subsequent fluorescence detection was used to determine the PAHs levels in the cooperational hospitals in Changzhi and Taiyuan cities and the urinary 1-hydroxypyrene levels of the 297 pregnant women living Changzhi and Taiyuan cities during Nov.2009 to May 2010.NBNA was used to determine the development of neonatal neural behavior.The differences of PAHs levels in the urban air,the pregnant women urinary 1-hydroxypyrene levels and NBNA scores between Taiyuan and Changzhi were compared.Results There are significant differences of levels of pyrene,benz[a]anthracene,Chrysene,benz[a]pyrene,dibenz[a,h]anthracene in the urban air between Taiyuan and Changzhi（P〈0.10）.The median of urinary 1-hydroxypyrene levels in pregnant women of Taiyuan was 1.140 μg/mmolCr,（P25 was 0.457 μg/mmolCr,P75 was 2.678 μg/mmolCr）,the median of urinary 1-hydroxypyrene levels in pregnant women of Changzhi was 0.761μg/mmolCr,（P25 was 0.133.μg/mmoICr,P75 was 2.095 μg/mmolCr）.There are significant differences of urinary 1-hydroxypyrene levels in pregnant women between Taiyuan and Changzhi（t=-3.140,P=0.002）.There are significant differences of the NBNA scores,capacity scores,passive muscle tension scores,active muscle tension scores and general assessment scores between Taiyuan and Changzhi（P〈0.10）.There was correlation between NBNA scores and urinary 1-hydroxypyrene level in pregnant women.Conclusion The PAHs in the urban air during pregnancy may adversely affect the neonatal neurobehavioral development.