中文摘要：

目的：探讨精氨酸加压素受体（AVPR1A、AVPR1B）和催产素受体（OXTR）基因多态性在青少年男性暴力攻击行为发生中的作用,并进一步分析基因与基因的交互作用。方法：采用SNa Pshot基因分型技术对138名暴力攻击行为男性少教人员（暴力组）、98名非暴力男性少教人员（非暴力组）以及153名正常成年男性（正常组）的AVPR1A（rs1042615）、AVPR1B（rs28632197）、OXTR（rs13316193、rs2254298、rs53576、rs2268498、rs237885）进行基因分型检测,分析3组间的等位基因和基因型频率。采用多因子降维法（MDR）构建影响暴力攻击行为发生的基因-基因间交互作用模型。结果：暴力组AVPR1B基因rs28632197位点A等位基因频率明显高于非暴力组和正常组（P均〈0.017）,OR值分别为2.24及2.63,95%CI分别为（1.45～3.47）和（1.78～3.88）;暴力组与非暴力组及正常组在基因型分布差异有统计学意义（P〈0.05）,暴力组含A等位基因的基因型（AA/AG）明显高于非暴力组和正常组（P〈0.017）;其余位点组间差异无统计学意义。AVPR1B（rs28632197）与OXTR（rs53576）在暴力攻击行为的发生中存在基因间交互作用。结论：AVPR1B基因多态性可能与暴力攻击行为相关;AVPR1B与OXTR基因的交互作用可能增加暴力攻击行为的发生风险。

英文摘要：

Objective： To study the association between arginine vasopressin receptor and oxytocin receptor gene polymorphism with violent aggression in male adolescents,and to explore the gene interaction.Method： Seven single nucleotide polymorphisms（ AVPR1 A rs1042615, AVPR1 B rs28632197, OXTR rs13316193,rs2254298,rs53576,rs2268498,rs237885） were detected using SNa Pshot genotyping assay for138 young male violent offenders（ violent aggression group）,98 non-violence young male offenders（ non-violent group） and 153 normal adult controls（ normal group）. The distribution of allelic and genotypic frequencies in the case and control groups was analyzed. Results： The frequency of A allele in rs28632197 of AVPR1 B gene in violent aggression group was higher than that of the non-violence and normal groups（ P〈 0. 017,OR = 2. 24 and 2. 63,95% CI = 1. 45 ～ 3. 47 and 1. 78 ～ 3. 88）. The difference in genotype distribution was significant between the three groups（ P〈 0. 05）,the frequency AA / AG genotype was higher in violent group than that in non-violence group and normal group. There was no significant difference on genetic susceptibility among three groups. There was an interaction between AVPR1B（ rs28632197） and OXTR（ rs53576） gene. Conclusion：The variance of arginine vasopressin receptor 1B gene polymorphism may play a role in violent aggression in male adolescents,and the interaction of AVPR1 B gene and OXTR gene may have an increased susceptibility to violence towards others.