中文摘要：

背景：假体周围骨溶解以及伴随的无菌性松动是全关节置换翻修手术的最常见原因。研究发现钙调磷酸酶/活化T细胞核因子信号通路在磨损颗粒诱导假体周围骨溶解中发挥重要作用。目的：归纳总结钙调磷酸酶/活化T细胞核因子在磨损颗粒诱导骨溶解中的作用,为骨溶解相关疾病提供新思路和新理论。方法：计算机检索Pub Med数据1980年1月至2016年6月相关文献;检索词为＂CN/NFAT;CN/NFATsignaling pathways;Wear particles;osteolysis;osteoclasts;osteoblast＂。根据纳入排除标准对最终选定的72条文献进行分析探讨。结果与结论：骨溶解的发病机制涉及巨噬细胞和被磨损颗粒激活的各种促炎细胞因子的释放。骨骼发育是通过骨吸收和骨重建之间的动态平衡相互偶联,机体维持正常骨量和骨密度的基础是成骨细胞的骨重建和破骨细胞的骨吸收。在这个过程中,钙调磷酸酶/活化T细胞核因子信号传导通路正是与Ca~（2＋）信号和核因子κB受体活化因子配体参与破骨细胞分化相关的信号传导通路。破骨细胞和胞核因子κB受体活化因子配体分别在骨吸收的生理病理过程中及破骨细胞生成过程中发挥关键作用。

英文摘要：

BACKGROUND： Periprosthetic osteolysis and subsequent aseptic loosening are most common reasons forrevision after total joint replacements. Recently studies found that calcineurin/activated T cell nuclear factor（CN/NFAT） signaling pathway plays important roles in the pathogenic process of wear-induced inflammation and osteolysis. OBJECTIVE： To summarize CN/NFAT effects on wear particles-induced osteolysis, and to provide new ideas and new theories for osteolysis-related diseases. METHODS： We retrieved Pub Med for studies published from January 1980 to June 2016. The key words were ＂CN/NFAT, CN/NFAT signaling pathways, wear particles, osteolysis, osteoclasts, osteoblast＂. Finally, 72 studies were analyzed and explored according to inclusion and exclusion criteria. RESULTS AND CONCLUSION： The pathogenesis of osteolysis involves the activation of macrophages by wear particles and the release of various proinflammatory cytokines. Bone is continuously renewed through a dynamic balance between bone resorption and formation and is the fundamental basis for maintaining normal bone mass and architecture by osteoclasts and osteoblasts. In this process, CN/NFAT signaling pathway is the signal transduction pathway involved in the differentiation of Ca~（2＋） and nuclear factor kappa B receptor ligand. Osteoclasts play a significant role in both physiological and pathological bone resorption, and receptor activator of nuclear factor-κB ligand is the key cytokine that induces osteoclastogenesis.