中文摘要：

目的：探讨卡维地洛联合缬沙坦治疗慢性心力衰竭疗效及对心功能指标的影响。方法 ：回顾性分析72例慢性心力衰竭患者的临床资料,随机分为观察组和对照组各36例,对照组给予强心苷、利尿药的常规治疗,并口服卡维地洛,观察组在此基础上加用缬沙坦。疗程均为6个月,评价两组患者的临床疗效,比较两组患者治疗前后的心功能指标变化,观察不良反应和并发症。结果 ：观察组治疗的总有效率94.40%高于对照组的44.40%（P〈0.05）。治疗后,观察组患者的心率、血压明显降低,左心室射血分数改善显著优于对照组（P〈0.05）。两组患者未发生严重不良反应。结论 ：卡维地洛联合缬沙坦可有效改善心力衰竭患者的临床症状和心功能,减缓心衰,减慢心肌重构,且不良反应发生少,具有良好的安全性。

英文摘要：

Objective： To discuss the efficacy of carvedilol combined with valsartan in the treatment of patients with chronic heart failure （CHF） and its influence on cardiac function. Methods： The clinical data of 72 cases of patients with CHF were retrospectively analyzed and patients were randomly divided into an observation group and a control group with 36 cases each. The control group was given conventional treatment including cardiac glycoside and diuretics, and oral carvedilol. The observation group was given valsartan on the base of the control group. The treatment for both groups was lasted for 6 months. The clinical efficacy was evaluated, the changes of cardiac function indexes were compared between two groups before and after treatment and adverse reactions and complications were observed. Results： The total effective rate of the observation group was higher than that of the control group （94.40% vs 44.40%, P〈0.05）. After the treatment, the heart rate and blood pressure were significantly decreased and the improvement of the left ventricular ejection fraction was much better in the observation group than the control group （P〈0.05）. There was no severe adverse reaction occurred in either group. Conclusion： Carvedilol combined with valsartan therapy can effectively improve the clinical symptoms and cardiac function of the CHF patients, which can slow down heart failure and cardiac remodeling with less adverse reaction and good safety.