中文摘要：

以分散聚合法制备低交联度三聚氰胺甲醛（MF）微球,研究了pH和反应时间等对MF微球粒径、表面电位和溶解性的影响.以MF微球为模板,采用层层自组装法交替吸附聚谷氨酸（PGA）和壳聚糖（CS）,构建中空的PGA/CS微胶囊.采用偏光显微镜、纳米粒度及电位分析仪、红外和透射电镜等进行表征.结果表明,MF粒径及表面电位随pH值降低而减小,在盐酸中的溶解性随反应时间延长而变差.在自组装过程中,微球表面电位呈正负交替变化,表明以静电力为主要驱动力制得的空心微胶囊粒径均匀,分散良好,模型药物罗丹明可成功载入其中,有望成为优良的水溶性药物载体.

英文摘要：

Melamine-formaldehyde（MF） microspheres were prepared by dispersion polymerization.The inf-luences of pH value and reaction time on partical size,surface potential and solubility of MF microspheres were studied.Using MF microspheres as templates,hollow PGA/CS microcapsules were fabricated by layer-by-layer self-assembly technique.The templates and microcapsules were characterized by polarization microscope,nano-granularity and potential analyzer,IR and TEM.The results show that the partical size and surface potential of MF microspheres decrease with the reducing of pH and its solubility in hydrochloric acid becomes worse as the time grows.The main driving force is electrostatic force between PGA and CS,which is supported by alternating ζ potentials.The hollow microcapsules with uniform size and good dispersity shows successful loading of model drug rhodamine,which is expected to find application in excellent carriers of water-soluble drugs.