中文摘要：

目的 探讨认知行为治疗对首发未服药轻中度抑郁症患者脑功能的作用.方法 对13例首发未服药轻中度抑郁症患者及13例正常对照组进行静息态功能磁共振扫描,患者在6周的认知行为治疗后再次接受功能磁共振扫描.运用Dparsf软件计算被试全脑的局部一致性（Regional homogeneity,ReHo）值,采用SPM8软件进行两独立样本t检验以及配对t检验,以分别检测两组间以及抑郁组治疗前后的脑功能差异.结果 与正常对照组比较,患者治疗前右缘上回（t=-3.18,P＜0.05）和右额下回岛盖部（t=-2.99,P＜0.05）的ReHo值降低,且在治疗后趋于正常.患者治疗后左额中回眶面（t=3.24,P＜0.05）和右额中回（t=3.06,P＜0.05）的ReHo值较正常对照组增高.患者治疗后左海马（t=-3.92,P＜0.05）的ReHo值较治疗前增高.结论 认知行为治疗早期可能通过同时启动认知抑制系统的两个主要脑区（右额下回和背外侧前额叶皮质）而起作用.

英文摘要：

Objective To explore the effect of cognitive-behavior therapy（CBT） for the first-episode patients with mild to moderate depression using functional magnetic resonance imaging （fMRI） in resting-state.Methods 13 first-episode treatment-naive patients who suffered from major depressive disorder （MDD） from a mild to moderate degree and 13 matched healthy control subjects underwent fMRI scan.Afterwards,patients were scanned again after the 6-week CBT.The whole brain ReHo maps of subjects were calculated by DPARSF software.Two-sample t-test for comparison between groups and paired t-test for comparisons between pre-and post-treatment were conducted by SPM8.Results Compared with the controls,at baseline,patients exhibited decreased ReHo in right supramarginal gyrus（t=-3.18,P〈0.05） and right opercular part of inferior frontal gyrus（t=-2.99,P〈0.05） which tended to normalize after treatment.After treatment,patients exhibited increased ReHo in left middle frontal gyrus（t=3.24,P〈0.05） and right middle frontal gyrus（t=3.06,P〈0.05）.From pre-to post-treatment,patients showed that ReHo increased in hippocampus（t=-3.92,P〈0.05）.Conclusion CBT may have an effect on MDD via activating both right inferior frontal gyrus and dorsolateral prefrontal cortex in cognitive inhibition system.