研究了冷驯化条件下不同肾上腺能受体激动剂对中缅树鼩产热能力的影响,测定了其静止代谢率和非颤抖性产热。结果表明:冷驯化组中缅树鼩的静止代谢率(Resting metabolic rate,RMR)较对照组增加,β3-NST(注射β3-肾上腺素激动剂BRL37344)和NST(注射NE)较对照组均极显著增加。冷驯化组和对照组在注射NE和BRL37344后其耗氧量均有极显著的增加。对照组中缅树鼩的NST高于β3-NST,但两者之间差异不显著。冷驯化组中缅树鼩NST与β3-NST差异极显著。以上结果说明冷驯化可使中缅树鼩的产热能力显著增强,其BAT中可能存在有β3-肾上腺能受体(β3-adrenergic receptor,β3-AR),推测β3-AR可能并不是中缅树鼩BAT中唯一的肾上腺能受体,NE可能通过多种肾上腺能途径来增加产热,肾上腺能受体通路在中缅树鼩适应性产热中起到了重要作用。
his article mainly studies oneffect of different βAR agonists on the thermogenic capacity ofTupaia belangeri under the condition of cold exposure and tests Tupaia belangeri's resting metabolic rate (RMR) and nonshivering thermogenesis (NST). The results show that RMR increasesin the group' ofcold exposure compared with control group (out of cold exposure). But β3 NST and NST increase significantly compared with control group. After the injection of NE and BRL37344, the oxygen consumption increases obviously in both groups. NST is higher thanβ3_ NST in control group, but the differences are not obvious. In the group of cold exposure, the differences between NST and β3_NST are obvious. All of results indicate that the cold exposure makes theTupaia belangeri's thermogenic capacity stronger and there exists β3- AR in BAT. The article speculates thatβ3_ AR is not the only AR in BAT. Perhaps, and NE may enhance thermogenesis by many adrenergic approaches, which may play an important role in the adaptive thermogenesis in T. belangeri.