中文摘要：

目的探讨代谢综合征（MS）患者外周血单个核细胞（PBMC）瘦素受体（Leptin receptor，LepR）表达与代谢综合征（MS）的关系及在靶器官损害中的作用。方法正常对照组49例，MS组48例，记录并检测临床和生化指标。采用实时荧光定量PCR检测受试者PBMC LepR mRNA表达。采用高频超声检测受试者颈动脉脉内膜．中层厚度（IMT）、测量并计算颈动脉压力弹性系数（Ep）和颈动脉僵硬度（13）。结果两组年龄性别匹配。与对照组比较，MS患者PBMC LepR表达显著下调（0．92±0．33vs0．74±0．48，P=0．037）；多元线性回归结果，高密度脂蛋白（HDL）减低、增龄和体重指数（BMI）增大是LepR表达下调的独立危险因素。与对照组比较，MS患者IMT增厚[（0．53±0．13）mm vs（0．79±0．18）mm，P=0．000]；多元线性回归结果，LepR表达下调和低密度脂蛋白（LDL）升高是IMT增厚的独立危险因素。结论单核细胞LepR表达下调与MS发生和发展密切相关，是MS患者早期动脉粥样硬化病变的重要参与因素。

英文摘要：

Objective To investigate the expression of leptin receptor （LepR） on monocytes in metabolic syndrome （MS） and its role in the target-organ damage. Methods LepR expression on peripheral blood mononuclear cells （PBMC） was respectively determined by real-time quantitative PCR in 48 controls and 49 MS patients. All subjects underwent carotid ultrasonography measuring intima-media thickness （IMT）, pressure-strain elastic modulus （Ep） and stiffness （6）. Results Compared with age-and sex-matched controls, expression of LepR on PBMC was significantly reduced in MS patients （ 0. 92±0. 33 vs 0. 74±0. 48, P = 0. 037） ; Multivariate linear regression analysis showed that the lowered HDL, aging and increased BMI were independent risk factors for reduced LepR. Furthermore, significantly incremental IMT was found in MS patients when compared with controls [ （0. 53±0. 13 ）mm vs （0.79±0. 18 ） ram, P = 0. 000], which was demonstrated by multivariate linear regression analysis to be consequent upon reduced LepR and increased LDL. Conclusions Down-regulation of LepR on monocytes is close associated with initiation and development of MS. Moreover, it participates in atherogenic process in MS.