中文摘要：

大肿瘤抑制基因1（large tumor suppressor gene 1,lats1）是hippo信号通路中的关键组分之一,通过下调靶基因yap抑制肿瘤的发生和发展。研究发现,lats1在多种肿瘤组织中表达下调或缺失,被认为是一个抑癌基因。因此,lats1很可能成为一个新的恶性肿瘤分子标记和治疗靶点,该文就lats1在该领域的研究进展作一综述。

英文摘要：

lats1 is one of the key components in hippo signaling pathway and suppresses occurrence and development of tumors by down-regulating the target gene yap. Decrease or loss of the expression of lats1 is found in a wide variety of tumor tissues, and it is regarded as a tumor suppressor gene. Therefore, lats1 might be a new malignant tumor molecular biomarker and a potential therapeutic target. In this paper, we reviewed the research advances of lats1 in this filed.