中文摘要：

血脑屏障的破坏是引起脑缺血损伤及继发水肿、出血、炎症的微观原因。缺血缺氧和再灌注过程产生的自由基,以及后续基质金属蛋白酶的激活,是破坏血脑屏障结构和功能的重要分子机制。因而,在脑缺血早期及时抑制自由基产生并清除自由基,抑制基质金属蛋白酶的活性,是降低脑缺血血脑屏障损伤及其并发症的关键环节。本文将从血脑屏障损伤的角度,概述自由基与基质金属蛋白酶在脑缺血损伤过程中的作用。

英文摘要：

Cerebral ischemia results in the compromise of blood-brain barrier（BBB） integrity,leading to neurovascular complications,including cerebral hemorrhage,edema,and inflammation.Free radicals and matrix metalloproteinases（MMPs） are critically involved in the mechanism of BBB breakdown following cerebral ischemia and reperfusion.Scavenging free radicals and inhibiting activation of MMPs are potential strategies to protect BBB integrity and reduce ischemia complications.In this review,we will focus on the the role of free radicals and MMPs activation in BBB damages in cerebral ischemia.