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N-acetylcysteine protect lymphocytes and cytokines against heavy ion irradiation via counteracting the glutamate

期刊名称：《中国科学院近代物理研究所和兰州重离子研究装置年报：英文版》
时间：0
分类：Q691[生物学—生物物理学] TQ936.21[化学工程]
作者机构：[1]Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China, [2]Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China, [3]Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China, [4]Department of Chemistry & Biochemistry, University of Delaware, Newark, DE 19711, USA, [5]Department of Abdominal Surgical Oncology, Cancer lnstitute and Hospital, Chinese Academy of Medical Sciences, Beiiing 100021, China
相关基金：Supported by National Basic Research Program （973 Program）（No. 2010CB834202）, National Natural Science Foundation of China （No. 10835011）, Key Scientific Technology Research Projects of Gansu Province （Nos. 0702NKDA045 and 0801NKDA001） and West Light Foundation （Doctor aid, 2009）

作者： XIE Yi[1,2,3], ZHANG Hong[1,2,3], WANG Yipei[4], LIU Yang[1,2,3], CHEN Yingtai[5]

关键词： N-乙酰半胱氨酸, 重离子辐照, 细胞因子, 保护作用, 谷氨酸, DNA双链断裂, 超氧化物歧化酶, 超氧阴离子自由基, N-acetylcysteine, ^12C^6＋ heavy ion, DNA damages, Oxidative stress, Lymphocytes and cytokines

中文摘要：

We evaluated the protective effect of N-acetylcysteine (NAC) on immunity system irradiated by 12C6+ ion beam. Kun-Ming mice were whole-body irradiated by 12C6+ ion at doses of 0, 0.5, 1, 1.5, 2, 2.5 and 3 Gy. The results showed that in saline group, the lymphocytes DNA double-strand breaks (DSBs), maleic dialdehyde, thymocytes number in G 0 /G 1 and apoptosis percentage increased with dose increment, and the levels of interferon-γ, glutathione, superoxide radical (SOD) and natural killer cells activity decreased with dose increment. However, there were no significant changes in NAC-treated group. The data indicated that pre-treatment with NAC could significantly remove the ROS by counteracting the glutamate, decrease excessive lipid peroxidation reaction and SOD damages, and protect DNA, lymphocytes and cytokines against irradiation.

英文摘要：

We evaluated the protective effect of N-acetylcysteine （NAC） on immunity system irradiated by ^12C^6＋ ion beam. Kun-Ming mice were whole-body irradiated by ^12C^6＋ ion at doses of 0, 0.5, 1, 1.5, 2, 2.5 and 3 Gy. The results showed that in saline group, the lymphocytes DNA double-strand breaks （DSBs）, maleic dialdehyde, thymocytes number in Go/G1 and apoptosis percentage increased with dose increment, and the levels of interferon-y, glutathione, superoxide radical （SOD） and natural killer cells activity decreased with dose increment. However, there were no significant changes in NAC-treated group. The data indicated that pre-treatment with NAC could significantly remove the ROS by counteracting the glutamate, decrease excessive lipid peroxidation reaction and SOD damages, and protect DNA, lymphoeytes and cytokines against irradiation.

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