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Roles of Tregs in development of hepatocellular carcinoma:A meta-analysis

ISSN号：1007-9327
期刊名称：《世界胃肠病学杂志：英文版》
时间：0
分类：R735.7[医药卫生—肿瘤;医药卫生—临床医学]
作者机构：Medical School of Chinese People’s Liberation Army, Department of Hepatobiliary Surgery,the 309~(th) Hospital of Chinese People’s Liberation Army, Department of Emergency Care,First Affiliated Hospital of Wenzhou Medical College, Burns Institute,First Hospital Affiliated to the Chinese PLA General Hospital
相关基金：Supported by National Natural Science Foundation of China,No.81130035,No.81372054,No.81071545,and No.81121004;the National Basic Research Program of China,No.2012CB518102

作者： Hong-Qiang Zhao, Wei-Min Li, Zhong-Qiou Lu, Yong-Ming Yao

关键词： HEPATOCELLULAR, carcinoma, REGULATORY, T, cells, Meta-a, Hepatocellular carcinoma, Regulatory T cells, Meta-analysis, Tumor escape, Cellular immunity

中文摘要：

AIM:To assess systematically the association between regulatory T cells(Tregs)and hepatocellular carcinoma(HCC).METHODS:We searched Medline,Embase and Wanfang databases for literature on the populations of Tregs in HCC patients and controls,using the pooled OR and 95%CIs for assessment.There were no limitations with respect to publication date or language.The references of qualifying articles were also searched.We excluded studies with unclear data or overlapping studies.Twenty-three studies met our criteria,and the quality of these studies was assessed using the Scottish Intercollegiate Guidelines Network(SIGN).The meta-analysis of association between Tregs and HCC was undertaken using the random-effects approach,as described by DerSimonian and Laird.Subgroup analysis was performed when at least three studies were available.Potential publication bias was assessed by visual inspection of the funnel plot,and an asymmetric plot suggested possible publication bias.RESULTS:Twenty-three studies with a total of 1279HCC patients and 547 healthy volunteers as controls were enrolled.The frequency of circulating Tregs in HCC patients was 87%higher than in healthy controls(OR=1.87,95%CI:1.49-2.34).The frequency of Tregs in the HCC tumor microenvironment was significantly higher than that in tumor-surrounding tissue and biopsy specimens from healthy livers(OR=4.04,95%CI:2.10-7.79,P=0.000;OR=2.869,95%CI:2.16-3.82,P=0.000).However,subgroup analyses based on the different types of tumors or patient characteristics such as tumor size,tumor number orαfetoprotein(AFP)levels in HCC patients,showed that populations of Tregs as a whole were not significantly changed between groups(P】0.05 for all).CONCLUSION:There is an obvious association between Tregs and pathogenesis of HCC.Further welldesigned clinical studies are warranted to illustrate the potential role of Tregs in HCC.

英文摘要：

AIM: To assess systematically the association between regulatory T cells (Tregs) and hepatocellular carcinoma (HCC).

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