中文摘要：

目的建立兔特异性动脉瘤数值模型并分析其血流动力学特征。方法采用外科手术结合弹性蛋白酶诱导法建立兔特异性动脉瘤数值模型,计算动脉瘤体颈比（AR）,采用ANSYS CFX软件对动脉瘤的血流动力学特征如壁面切应力、流场、冲击域、压力场等进行数值模拟计算,并统计分析。结果动脉瘤AR值最大为1.79,最小为0.49。壁面切应力在动脉瘤流入道最高（28.39 Pa）,瘤顶次之（11.39 Pa）,流出道最低（6.64 Pa）。动脉瘤流入道和流出道壁面切应力梯度变化与AR值均无相关性（r=-0.016,P=0.957;r=0.185,P=0.527）。流场复杂性与AR值显著相关（r=0.627,P=0.016）,而动脉瘤颈口的冲击域宽度与AR值相关性不显著（r=0.38,P=0.18）。动脉瘤顶压力最高（3 046.72Pa）,动脉瘤流入道和流出道压力梯度变化与AR值均无相关性（r=0.202,P=0.489;r=-0.147,P=0.616）。结论兔特异性动脉瘤数值模型的血流动力学特征与病人特异性动脉瘤的血流动力学特征基本吻合,是研究动脉瘤的理想模型。

英文摘要：

Objective To establish a rabbit-specific numerical model of intracranial aneurysm and analyze the hemodynamic features of the model.Methods The rabbit-specific intracranial aneurysm model was established by using surgery combined with elastase-induction method.The ratio of body to neck of aneurysm（aspect ratio,AR） was calculated.The numerical simulation calculations of the hemodynamic features including wall shear stress,flow field,impact zone and pressure profile of the aneurysm were executed by ANSYS CFX.The results were further analyzed statistically.Results The maximum of aneurysm AR was 1.79,and minimum was 0.49.The maximum wall shear stress magnitude（28.39 Pa） was in the influx of aneurysm,lower wall shear stress magnitude（11.39 Pa） at the dome of the aneurysm and minimum wall shear stress magnitude（6.64 Pa） in the spout.There was no correlation between the gradient change of wall shear stress in the influx of aneurysm and AR（r=-0.016,P=0.957）,and the gradient change of wall shear stress in the spout of aneurysm was not correlated with AR（r=0.185,P=0.527）.The complexity of flow field was significantly correlated with AR（r=0.627,P=0.016）,but impact zone width in the neck was not correlated with AR（r=0.38,P=0.18）.The pressure reached peak at the dome of the aneurysm（3 046.72 Pa）.There was no correlation between the gradient change of pressure in the influx of aneurysm and AR（r=0.202,P=0.489）,and the gradient change of pressure in the spout of aneurysm was not correlated with AR（r=-0.147,P=0.616）.Conclusions The hemodynamic features of rabbit-specific numerical intracranial aneurysm model are consistent with those of patient-specific aneurysms.The model is ideal for the research of aneurysm.