中文摘要：

引言 脱氢枞胺是松香中脱氢枞酸的衍生物,它是一种光学活性化合物,可用作外消旋体的光学拆分剂。脱氢枞胺及其衍生物如季铵盐、醋酸盐、五氯酚盐、N,N-二羧甲基衍生物等有一定的杀菌效果,从而被应用于杀菌剂。目前文献报道主要集中在脱氢枞胺氨基的改造,而对B环和C环改造的文献报道很少,因此本文研究了脱氢枞胺的三氟乙酰化、硝化以及三氟乙酰基的水解等反应,合成了在脱氢枞胺的C环上不同位置含有不同数量硝基的新化合物,表征了其化学结构并测定了其抗菌生物活性,为研究脱氢枞胺衍生物的结构与生物活性关系及开发新型杀菌剂提供参考。

英文摘要：

Three derivatives of dehydroabietylamine were synthesized from dehydroabietylamine through trifluoro-acetyltion,nitration and hydrolysis.Two of them were first reported as new compounds.The compounds were characterized by FT-IR,1H NMR,EI-MS,elemental analyses and HRMS.Their bactericidal activities were investigated,and the results indicated that 12-nitro-dehydroabietylamine and 12,14-dinitro-dehydroabietylamine had strong bactericidal activity against E.coli,Staphylococcus aureus,Pseudomonas fluorescens.