中文摘要：

目的提高散发性克雅病临床诊断水平，降低其误诊率。方法回顾性分析11例克雅病患者临床表现及早期误诊情况。结果11例克雅病患者早期误诊为阿尔茨海默病4例，病毒性脑炎3例，脑梗死2例，路易体痴呆2例，脑脊液14—3—3蛋白阳性6例。结论克雅病的早期临床表现极不典型，较易误诊；多次复查脑电图、磁共振弥散加权成像、脑脊液14—3—3蛋白是诊断本病的重要手段。

英文摘要：

Objective To improve the clinical practical diagnosis of sporadic Creutzfeldt-Jakob disease and decrease the probability of misdiagnosis. Methods Clinical manifestations of 11 cases of Creutzfeldt-Jakob disease misdiagnosed in the early stage were reviewed. Results Eleven cases of Creutzfeldt-Jakob disease were misdiagnosed as Alzheimer＇s disease （4 cases）,viral encephalitis （3 cases）,cerebral infarction （2 cases） and dementia with Lewy bodies （2 cases） in the early stage. Cerebrospinal fluid 14-3-3 protein was positive in 6 cases. Conclusions The clinical manifestations of Creutzfeldt-Jakob disease in the early stage are atypical and tend to be misdiagnosed; repetitive EEG,diffusion weighted imaging and cerebrospinal fluid 14-3-3 protein are essential to diagnosis.