中文摘要：

目的：建立食源性肥胖大鼠模型，观察高脂配方对制造食源性肥胖大鼠动物模型的影响。方法：用搭配的高脂饲料喂养大鼠12周，观察摄食量、体重、体长，计算肥胖指数，普通饲料组作为对照组。结果：喂养12周后，高脂组大鼠体重为（633．50±32．71）g，普通组大鼠体重为（525．30±20．47）g，经统计学处理，高脂组与普食组有显著性差异（P〈0．01），另外高脂组的Lee’s指数与普食组比较差异具有统计学意义（P〈0．05）。结论：用搭配的高脂饲料制作食源性肥胖大鼠模型，致肥效果明显。

英文摘要：

Objective ： To establish diet - induced obese rats model and observe the influence of high - fat - diet on obese rats. Methods ： Rats of model group were fed with the collocating high - fat - diet for 12 weeks. And then, weekly weight and body length were compared with those of normal control group. Results ： The weight of model group was （633.50 ± 32.71 ） g. That of normal control group was （525.30 ± 20.47 ） g. There was significant difference between the two groups （P 〈 0.01 ）. Lee＇s index was sig- nificantly increasing in model group （ P 〈 0.05 ）. Conclusion ： High - fat - diet can induce obesity. The collocating HFD had obvi- ous effect of inducing obesity.