中文摘要：

合成了一类基于四氢吡喃/四氢呋喃醚结构的酸敏感连接单元1a和1b,该连接单元的两端均为易反应的活性官能团,其结构经1H NMR、13C NMR、IR和HRMS表征,并合成了一种含四氢吡喃醚结构的模型化合物以及含四氢呋喃醚结构的两亲性嵌段共聚物,其中聚乙二醇（PEG）为亲水片段,聚乳酸（PLA）为疏水片段,其结构经1H NMR、IR以及GPC的表征,并测定了该嵌段共聚物自组装胶束的粒径大小、临界胶束浓度（CMC）以及常温下的稳定性.实验结果表明该类酸敏感嵌段共聚物自组装胶束具有良好的发展前景.

英文摘要：

A series of acid cleavable linkers based on tetrahydropyran/tetrahydrofuran （THP/THF） ether were synthesized, in which both of the two terminals are active group which is easy to react with other compounds. The structures for these linkers la and lb were confirmed by 1H NMR, 13C NMR, HRMS, and IR. Model compound containing THP linkage was synthesized. Furthermore a pH-responsive amphiphilic diblock copolymer containing tetrahydrofuran （THF） linkage in which hydrophilic segment was poly（ethylene glycol） （PEG） and hydrophobic segment was hydrophobic polylactic acid （PLA） was synthesized and characterized by 1H NMR, IR and gel permeation chromatography （GPC）. The size, stability and critical micelle concentration （CMC） of diblock copolymer micelle were also evaluated. The preliminary experimental results show that the acid sensitive amphiphilic diblock copolymer micelle is a potential alternative for future drug delivery.