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中文摘要：
内脏脂肪组织特异性丝氨酸蛋白酶抑制物（Vaspin）是新发现的脂肪因子,主要由内脏脂肪组织产生,它的分泌和表达受多种因素的影响,并与肥胖、2型糖尿病、动脉粥样硬化（Atherosclerosis,As）等有关。Vaspin具有胰岛素增敏性、改善糖耐量、抑制血管炎症反应等作用,对这些作用机制的认识,能为防治动脉粥样硬化提供新的治疗靶点。
英文摘要：
A visceral adipose tissue-derived serine protease inhibitor（vaspin） is a novel adipocytokine, which is mainly secreted from visceral adipose tissue. And the secretion and expression of vaspin are influenced by multiple factors. Vaspin has a relationship with obesity and type 2 diabetes mellitus and atherosclerosis（As）. It has been assumed that vaspin palys an important role in the pathogenesis of insulin-sensitizing and glucose intolerance and anti-vascular inflammation. The entire understanding the action mechanism of vaspin might enable the development of novel therapeutic targets of atherosclerosis.
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