中文摘要：

合成了复合脂质N，N-二-十六烷基-N^α-6-（3-三乙氧硅烷基）丙基二甲胺基己酰基-L-丙氨酰胺（1），其结构经薄层色谱（TLC）、^1 H核磁共振（NMR）及元素分析表征得以证实。将该脂质分散到水溶液中并进行超声，其头部将水解进而缩合形成表面具有陶瓷或硅覆盖的脂质体，因此将其命名为Cerasome。用十六烷基三甲基溴化铵（CTAB）作为添加的表面活性剂，采用荧光分光光度计通过测定脂质体的光散射强度，对Cerasome及作为对照的合成肽脂N，N-二-十六烷基-N^α-6-三甲胺基己酰基-L-丙氨酰胺（2）和磷脂酰胆碱（3）脂质体的稳定性进行了评价，结果Cerasome表现出了异常高的稳定性。

英文摘要：

An organic - inorganic hybrid lipid N, N - dihexadecyl - N^α - [ 6 - [ （3 - triethoxysilyl） propyldi -methylammonio ] hexanoyl I alaninamide bromide was synthesized. The compound was characterized by thin layer chromatography,^1 HNMR spectra and elemental analysis. The lipid has a （triethoxysilyl）propyl group as an inorganic precursor on the quarternized ammonium nitrogen. Upon sonication of the lipid dispersed in aqueous HEPES buffer, it self- assembles with concomitant hydrolysis of the inorganic precursor moiety followed by condensation to give partially ceramic - or silica -coated liposome （Cerasome）. Morphological stability of the Cerasome was evaluated by light scattering intensity employing a fluorescence spectrophotometer with the addition of the surfactant CTAB. For comparison, the morphological stability of liposomes derived from a synthetic peptide lipid N, N - dihexadecyl - N^α - [ 6 - （ trimethylam- monio） hexanoyl ] alanin - amide bromide （2） and a phospholipid dimyristoylphosphatidylcholine （3） were examined under the similar sonication conditions. The results indicate that the Cerasome is highly stable as compared to the conventional lioosornes.