中文摘要：

RNA methylation 修正被作出对有利的裁决年的十年，它发生在众多的种类的不同 RNA 类型，和他们的分发是种类特定的。然而，人们很少知道他们的生物功能。在真核细胞的送信人 RNA (mRNA ) 有几识别 methylation 修正，例如在帽子， N6-methyl-2-O-methyladenosine (m6Am ) ，在帽子以内的 2-O-methylation (Nm ) 和内部位置的 N7-methylguanosine (m7G ) ，并且内部 N6-methyladenosine (m6A ) 和 5-methylcytosine (m5C ) 。在他们之中， m7G 帽子更清楚地被学习并且发现了在象 mRNA 翻译，稳定性和原子出口一样的几个重要 mRNA 过程有重要角色。在 mRNA 的最丰富的修正在 1970 年代被发现并且被建议了在拼接的 mRNA 工作的 m6A，翻译，稳定性，运输等等。m6A 作为由人的胖质量直接是 demethylated 的第一 RNA 可逆修正被发现了，肥胖联系了蛋白质(FTO ) 和它的相当或相同的事物蛋白质，完化修理相当或相同的事物 5 (ALKBH5 ) 。FTO 有到通过二在氧化上的中介的 A 的 demethylases m6A 说的特殊 demethylation 机制：N6-hydroxymethyladenosine (hm6A ) 和 N6-formyladenosine (f6A ) 。二最新发现的 m6A demethylases， FTO 和 ALKBH5，显著地控制精力动态平衡和精子发生分别地，显示动态、可逆的 m6A，类似于 DNA 和 histone 修正，在生物王国起宽广作用并且带给我们新兴的领域 RNA Epigenetics。5-methylcytosine (5mC ) 广泛地作为在 DNA 的一个 epigenetic 标记被学习了，但是在 mRNA 的 m5C 很少被探索。定序的二硫化物证明 m5C 是在 mRNA 的另一丰富的修正，建议它可能是另一个 RNA epigenetic 标记。这评论在 mRNA 集中于主要 methylation 修正从当前的知识描述他们的形成，分发，功能和 demethylation 并且在功能的研究上提供未来观点。

英文摘要：

RNA methylation modifications have been found for decades of years, which occur at different RNA types of numerous species, and their distribution is species-specific. However, people rarely know their biological functions. There are several identified methylation modifications in eukaryotic messenger RNA （mRNA）, such as NT-methylguanosine （mVG） at the cap, Nr-methyl-2＇-O-methyladenosine （m6Am）, 2＇-O-methylation （Nm） within the cap and the internal positions, and internal N6-methyladenosine （m6A） and 5-methylcytosine （mSC）. Among them, mTG cap was studied more clearly and found to have vital roles in several important mRNA processes like mRNA translation, stability and nuclear export, m6A as the most abundant modification in mRNA was found in the 1970s and has been proposed to function in mRNA splicing, translation, stability, transport and so on. mrA has been discovered as the first RNA reversible modification which is demethylated directly by human fat mass and obesity associated protein （FRO） and its homolog protein, alkylation repair ho- molog 5 （ALKBH5）. b-TO has a special demethylation mechanism that demethylases m6A to A through two over-oxidative intermediate states： N6-hydroxymethyladenosine （hm6A） and Nr-formyladenosine （frA）. The two newly discovered m6A demethylases, bTO and ALKBH5, significantly control energy homeostasis and spermatogenesis, respectively, indicating that the dynamic and reversible mrA, analogous to DNA and histone modifications, plays broad roles in biological kingdoms and brings us an emerging field ＂RNA Epige- netics＂. 5-methylcytosine （5mC） as an epigenetic mark in DNA has been studied widely, but mSC in mRNA is seldom explored. The bisulfide sequencing showed mSC is another abundant modification in mRNA, suggesting that it might be another RNA epigenetic mark. This review focuses on the main methylation modifications in mRNA to describe their formation, distribution, function and demethylation from the current knowledge and t