Diels-Alder反应具有立体专一性和很好的区域选择性,已被大量应用于天然有机化合物、香料、药物等的合成中。一般说来,Diels-Alder反应在加热条件下即能发生,但加热往往导致反应的区域选择性和立体专一性下降,而研究表明,路易斯酸催化下的Diels-Alder反应在不同程度上表现出或反应速度加快,或产率提高,或条件温和,尤其是区域选择性和立体专一性得到提高等良好特性。
The ytterbium chloride catalyzed Diels-Alder reaction of acrylate with furan was studied. The influence of reaction conditions upon the yield and stereoselectivity of the products was discussed emphatically.