中文摘要：

碳纳米管探针是原子力显微镜新一代探针，在柔软生物样品的微观形貌表征领域有重要的应用价值．研究和分析了碳纳米管原子力显微镜探针和普通硅探针对小鼠IgG蛋白形貌的袁征能力．通过原子力显微镜实验对比研究发现，普通硅探针容易对IgG蛋白产生显著的压痕，而碳纳米管探针具有良好的柔韧性，能显著减小成像时对柔软的生物样品的损伤硅探针与样品间存在较大的毛细力，会降低探针的分辨率；由于碳纳米管疏水，纳米管探针能显著减小毛细力的影响，能高分辨率地检测IgG蛋白，充分发挥纳米管探针的高分辨率优势．

英文摘要：

Carbon nanotube （CNT） probes have high performance in atomic force microscope （AFM） and are of great value in nano metrology of soft biological samples. The performance of a CNT probe and ordinary Si probe was studied with mice immunoglobulin G（IgG） proteins scanning. Experimental results show that the ordinary Si probe may produce large probe indentation while scanning the soft proteins for it is hard and brittle. Due to its good elastic buckling property,the CNT probe can greatly reduce the damage to the IgG proteins. In addition,adhesion forces may greatly degrade Si probe＇s image resolution. Because the CNT probe is hydrophobic,it can well overcome the impact of adhesion forces on its image resolution and shows high image resolution.