中文摘要：

目的探讨乏氧显像剂^18F-氟赤式硝基咪唑（^18F—FETNIM）在食管癌细胞ECa109乏氧监测中的应用价值。方法传代至2～3代的ECa109细胞，常氧环境下分别予以0、2、4、6、8Gyx线照射，加入等量”F．FETNIM显像剂后分别于5、30、60、120、180min用γ井型测量仪测定其放射性计数，计算摄取率。结果^18F—FETNIM在ECa100细胞中的摄取，0Gy组细胞的摄取率随时间延长而增高，180min达最高，其余各组细胞随照射剂量增加，摄取率峰值逐渐前移，且峰值均高于0Gy组。结论^18F—FETNIM可用于食管癌细胞乏氧情况监测，为临床优化化疗方案提供依据。

英文摘要：

objective To investigate the monitoring value of hypoxic tracer fluorine-18-fluoroerythronitroimidazole （ ^18 F- FETNIM） in esophageal cancer ECa109 cells line. Method ECa109 cell line, which had been passaged 2-3 times and cultured under normoxic environment, were given different doses of X-ray irradiation （0 Gy,2 Gy ,4 Gy ,6 Gy ,8 Gy）, separately. The uptake of ^18F-FETNIM in cell line were counted at 5 min,30 min,60 m/n, 120 min, 180 min separately after adding the hypoxia imaging agent ^18F-FETN/M by Well γ-type measuring instrument. Result The cell line uptake rate of 0 Gy group increased continuously as the time pass and reached the peak at 180 rain ,while the other groups, the time to uptake peak were shortened and become shorter as the X-ray radiation dose enhanced step by step. All the peak uptake rate in X- ray radiation groups were higher than that in 0 Gy group. Conclusion The uptake of ^18F-FETNIM for esophageal cancer cells can be used for the monitoring of hypoxia, in order to optimize the clinical programs provide a basis for radiotherapy and chemotherapy.