中文摘要：

周围神经损伤（PNI）可导致轴突退变和脱髓鞘。脱髓鞘后施万细胞将去分化并形成Bungner带，进而为轴突再生及其再髓鞘化创造条件，所以脱髓鞘对PNI修复具有重要意义。研究发现，转录因子c-Jun在施万细胞脱髓鞘过程中表达增高，而且许多分子可通过调控c-Jun影响周围神经脱髓鞘。因此本文围绕c—Jun信号通路对PNI脱髓鞘的调控机制综述如下。

英文摘要：

After peripheral nerve injury （PNI）, myelinated Schwarm cells undergo demyelination, dedifferentiation and proliferation, then migrate along basal lamina tubes and align to form the longitudinal cell strands known as bands of Bungner, which creates suitable conditions for axonal regeneration and remyelination. By reviewing literature, we found that the expression of a transcriptional factor c-Jun increased during demyelination process after PNI, and increasing evidences suggested that demyelination and c-Jun signaling pathways were closely related. This review summarized the research situation and progress of c-Jun signaling pathways regulating demyelination process after peripheral nerve injury.