中文摘要：

目的 ：检测原发性肝细胞癌患者血清中血管细胞黏附分子-1（vascular cell adhesion molecule-1,VCAM-1）的表达水平,并探讨其临床意义。方法：采用酶联免疫吸附测定法（enzyme-linked immunosorbent assay,ELISA）检测414例原发性肝细胞癌患者、120例肝炎患者和92例健康人血清中VCAM-1的表达水平,分析血清中VCAM-1的水平与肝细胞癌患者临床病理特征的相关性及与患者生存期的关系。结果 ：肝细胞癌患者血清中VCAM-1的表达水平明显高于肝炎患者及健康对照组（P〈0.000 1）,且与血清中甲胎蛋白（alpha-fetoprotein,AFP）的表达水平密切相关（P=0.021）。Kaplan–Meier分析结果表明,VCAM-1表达水平高的肝细胞癌患者生存期短（P=0.023）。结论 ：血清中VCAM-1的表达水平可以作为原发性肝细胞癌诊断和预后的潜在标志物。

英文摘要：

Objective： To examine the level of serum vascular cell adhesion molecule-1（VCAM-1） in patients with primary hepatocellular carcinoma（HCC）, and to explore its clinical significance.Methods： Serum specimens from 414 HCC patients were included in this study, in addition to samples from 92 healthy individuals and 120 patients with chronic hepatitis B virus（HBV） infection. Serum VCAM-1 levels were detected using an enzyme-linked immunosorbent assay（ELISA）, and the correlation between VCAM-1 levels and clinical features was evaluated.Results： The serum VCAM-1 level was significantly higher in HCC patients than in healthy individuals or patients with chronic HBV infection（HBV carriers）（P 〈 0.000 1）. Moreover, the serum VCAM-1 level was correlated with alpha-fetoprotein（AFP） levels（P = 0.021） but not with gender, age, tumor size, histological grade, HBV infection, intrahepatic metastasis or cirrhosis in HCC patients. Kaplan-Meier analysis indicated that higher VCAM-1 level was associated with shorter survival in HCC patients（P = 0.023）.Conclusion： These results suggest that the serum level of VCAM-1 may serve as a potential diagnostic and prognostic biomarker for primary HCC patients.