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APE1 siRNA重组腺病毒增强贝伐单抗对移植骨肉瘤的治疗作用
  • 期刊名称:中国肿瘤生物治疗杂志??
  • 时间:0
  • 页码:331-335
  • 语言:中文
  • 分类:R730.6[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构:[1]浙江省杭州市肿瘤医院肿瘤内一科,310002, [2]浙江省杭州市第一人民医院神经内科,310006
  • 相关基金:国家自然科学基金资助项目(30801368).
  • 相关项目:双功能基因APE1氧化修饰调控VEGF表达及其机制的研究
作者: 仲召阳|
中文摘要:

目的探讨血液学检测指标评估晚期肿瘤患者营养状况的准确性。方法对杭州市肿瘤医院2014年1~9月收治的100例Ⅲ~Ⅳ期晚期恶性肿瘤患者清蛋白、血红蛋白、总蛋白、空腹血糖、乳酸脱氢酶、胆固醇、三酰甘油、尿素氮和肌酐等指标进行测定,对PG-SGA调查问卷进行回顾性分析,PG-SGA量表评估其营养状况,评分为A级(n=70)、B级(n=8)、C级(n=22),对应将患者分为营养良好、中度营养不良(潜在性营养不良)、严重营养不良,以PG-SGA评分作为标准,评估上述各项血液学检测指标评估患者营养状况的准确性。结果在PG-SGA分级的A、B、C级之间晚期肿瘤患者血红蛋白和血清清蛋白比较差异均有统计学意义(P〈0.05)。血红蛋白PG-SGAA级与C级患者间比较差异有统计学意义(P=0.000),B级与C级患者间比较差异有统计学意义(P=0.025),清蛋白PG-SGAA级与B级患者间比较差异有统计学意义(P=0.003),A级与c级患者间比较差异有统计学意义(P=0.000)。结论血红蛋白、血清清蛋白检测指标在晚期肿瘤患者营养状况评估方面具有较高的准确性。

英文摘要:

Objective To investigate the detection of malnutrition in patients with advanced cancer indicators for accuracy. Methods From January to September in 2014,100 patients with advanced Ⅲ-Ⅳ stage cancer were treated in Hangzhou cancer hospital. The clinical data of these patients were retrospectively reviewed, the data including albumin, hemoglobin, total protein, fasting blood-glucose, lactate dehydrogenase, cholesterol, triglycerides, blood urea nitrogen and creatinine and other indicators. Patients' nutritional status was evaluated by PG-SGA scale and according to the result was graded into PG-SGA grade A(n= 70), B(n= 8) and C(n= 22). Patients were divided into good nutrition,moderate malnutrition(potential potentially malnutrition), severe malnutrition groups. Take PG-SGA score as a standard, evaluation of the above-mentioned nutritional status of patients with hematology detection index evaluation accuracy. Results There were significant differences in patients with advanced malignant tumor in hemoglobin and serum albumin among PG-SGA grade A,B arid C(P〈0.05). Hemoglobin showed difference between patients of PG-SGA grade A and C(P=0. 000) ,grade B and C(P=0. 025). Albumin showed difference in patients between grade A and B(P=0. 003) ,grade A and C(P=0. 000). Conclusion Hemoglobin,and serum albumin can be used for evaluating nutritional status in patients with advanced cancer.

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