中文摘要：

TET2为TET家族成员之一,是一个与造血系统发育密切相关的肿瘤抑制基因。近年研究发现,TET2通过将DNA上的5-甲基胞嘧啶（5-mc）氧化为5-羟甲基胞嘧啶（5-hmc）,参与DNA的去甲基化过程。体细胞中TET2基因异常会导致骨髓生成异常及恶性髓系疾病的发生。本文将就TET2的结构与功能,TET2基因突变与不同类型髓系肿瘤的关系进行综述。

英文摘要：

TET2 gene is a member of TET oncogene family.It has been reported as a tumor suppressor gene with important roles in myelopiesis.Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine（ 5-mc） into 5-hydroxymethylcytosine（ 5-hmc）.Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies.In this review,the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.