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Effects of resistin-like molecule β over-expression on gastric cancer cells in vitro
  • ISSN号：1007-9327
  • 期刊名称：《世界胃肠病学杂志：英文版》
  • 时间：0
  • 分类：Q6[生物学—生物物理学]
  • 作者机构：[1]华中科技大学同济医学院附属协和医院外科,湖北武汉430022, [2]华中科技大学同济医学院附属协和医院病理科,湖北武汉430022
  • 相关基金：国家自然科学基金资助项目（No.81071997;No.81072073）
作者： Li-Duan Zheng[1], Ling Tong[1], Chun-Lei Yang[2], Teng Qi[2], Meng Qi[2], Qiang-Song Tong[2]
关键词： 肠凝集素1, 生物学功能, Intelectin 1, Biological function
中文摘要：

肠凝集素1 （intelectin 1,ITLN1） 是1998年Komiya等[1]运用原位杂交筛选法从小鼠肠帕内特细胞 （肠腺嗜酸性粒细胞） 中分离的一种新基因.2003年,Yang等[2]在进行人类网膜脂肪cDNA文库的表达序列标签测序时,发现了一种腹腔网膜脂肪组织特异性分泌的蛋白因子,命名为网膜素 （omentin） .后续研究发现人类ITLN1与网膜素的编码基因和氨基酸序列相同,于是美国国立生物技术信息中心统一命名为ITLN1.鉴于ITLN1在内分泌疾病、心血管疾病、炎症、肿瘤等诸多方面中的作用,引起了学界广泛的关注.本文从ITLN1的基因和蛋白结构、分布、生物学功能等方面进行综述.

英文摘要：

Human intelectin 1 （ITLN1）, also named as omentin 1, is a secretory trimetric protein and host defense lectin that binds to bacterial galactofuranose. It is primarily expressed in visceral adipose tissue and is highly abundant in plasma. ITLN1 can trigger Akt signaling and enhance insulin-stimulated glucose uptake in human omental adipocytes. It also has anti-microbial, immunomodulatory and anti-inflammatory properties. Recent studies reveal a close linkage between ITLN1 and malignant pleural mesothelioma. This article reviews the progress in the systemic biological function of ITLN1.

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期刊信息
  • 《世界胃肠病学杂志：英文版》
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  • 主办单位:百世登出版集团有限公司
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  • 邮编：100023
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  • 电话：0351-4078656
  • 国际标准刊号：ISSN：1007-9327
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  • 被引量:12408