中文摘要：

以E9日龄至E14日龄昆明种正常小鼠胚胎为材料,利用质粒扩增的、地高辛标记的基因探针在组织切片上进行DNA-mRNA分子原位杂交,研究了p21基因在小鼠胚胎发育过程中的表达.结果表明：p21基因从E10日开始参与小鼠胚胎发育,其表达特异性随着胚胎发育进程逐渐增强,与它在细胞周期中的负调控作用相一致.p21基因表达强度较稳定,与其mRNA稳定有关.

英文摘要：

Using in situ hybridization technique with dig labeled probe, the expression of p21 gene in mice＇ s embryo development has been studied in this paper. The results can be summarized as follows：p21 gene does not take part in the formation of organ primordial during the development of embryo of age 9ds. It starts to express in the embryo of age 10ds and then express stronger with the development of tile embryo. It seems to suggest that p21 gene is concord with the negative regulation of cell cycle. The little change in expression strengthen may relates with its stable mRNA.