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中文摘要：
本研究主要探讨混合饲喂枯草芽孢杆菌RJGP16和猪源乳酸杆菌B1对仔猪肠道肠绒毛发育的影响,以及这两种益生菌在体内拮抗大肠埃希氏菌K88的能力。试验选取8窝新生仔猪为研究对象,分别于0、7、11和26日龄经口腔灌服枯草芽孢杆菌菌液（活菌数1.0×109 CFU·mL-1）、猪源乳酸杆菌菌液（活菌数1.0×109 CFU·mL-1）、枯草芽孢杆菌和猪源乳酸杆菌混合菌液（体积比1∶1）,以及对饲喂混合菌液的试验组进行大肠埃希菌K88的攻毒试验。试验结果表明,同时饲喂枯草芽孢杆菌和猪源乳酸杆菌能显著提高十二指肠（P〈0.05）和回肠（P〈0.01）的肠绒毛高度,增加十二指肠（P〈0.05）和空肠（P〈0.01）绒毛的数量,降低空肠（P〈0.05）和回肠（P〈0.01）的隐窝深度,以及增加十二指肠（P〈0.05）、空肠（P〈0.05）和回肠（P〈0.01）的绒腺比。此外,同时饲喂这两种益生菌能有效地拮抗大肠埃希菌K88对仔猪肠道上皮的损伤。笔者的研究提示枯草芽孢杆菌和猪源乳酸杆菌对肠道绒毛的发育起到了促进作用,并能有效地提高抗感染能力。
英文摘要：
This study focused on the effects of co-administration of Bacillus subtilis RJGP16 and porcine Lactobacillus salivarius B1 on intestinal villus of piglets,as well as the antagonism between the probiotics and Escherichia coli K88 in vivo.Eight litters newborn piglets were orally administrated with B.subtilis（viable count 1.0×109 CFU·mL-1）,procine L.salivarius（viable count 1.0×109 CFU·mL-1）,these two kinds of probiotics（volume ratio 1：1） respectively,at 0,7,11 and 26 days after birth.After co-administration of the two probiotics,the piglets were inoculated with E.coli K88.The results showed that the co-administration of the two probiotics could significantly promote the villus height（VH） of duodenum（P0.05） and ileum（P0.01）,increase the villus number of duodenum（P0.05） and jejunum（P0.01）,lower the crypt depth（CD） of jejunum（P0.05） and ileum（P0.01）,and increase the villus height/crypt depth（VH/CD） of duodenum（P0.05）,jejunum（P0.05） and ileum（P0.01）.In addition,the co-administration of the two probiotics could effectively antagonize the injury caused by E.coli K88 to intestinal epithelium of piglets.These results suggested that the B.subtilis and L.salivarius could promote the development of the intestinal villus and increase the resistance to infection.
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