中文摘要：

目的：探讨局部晚期宫颈癌术前新辅助化疗（neoadjuvantchemotherapy，NACT）的疗效。方法：选择我院自2008年1月～2011年1月收治的43例Ib-Ⅱa期、局部肿块≥4cm的巨块型宫颈癌患者，采用紫杉醇加顺铂（TP）方案及博来霉素加顺铂（BP）方案行2个疗程的静脉化疗之后，全部患者均行广泛全子宫加盆腔淋巴结清扫术，观察其近期疗效。结果：本组43例巨块型宫颈癌应用NACT治疗，有效率分别为80％（TP）和78．26％（BP），没有明显差异。结论：宫颈癌术前新辅助化疗是安全有效的，宫颈癌的新辅助化疗缩小了局部病灶、提高了手术成功率，延长患者的生存期。

英文摘要：

OBJECTIVE： To evaluate the effect of preoperative neoadjuvant chemotherapy in cervical carcinoma. METHODS ： A total of 43 patients with FIGO stage I b - Ⅱ a cervical squamous carcinoma were divided into TP （ eisplatin ＋ bleomycin） group and BP （taxol ＋ cisplatin） group. BP program and TP program were given to preoperative patients during neoadjuvant chemotherapy. All patients completed two courses of treatment. After chemotherapy hysterectomy and Pelvic lymphadeneetomy were extented in these pa- tients. RESULTS： The effective rates were 80% （TP） and 78.26% （BP） respectively. There was no significant difference between TP group and BP group （ P 〉 0. 05 ）. CONCLUSION ： Preoperative neoadjuvant chemotherapy in early cervical cancer can significant- ly reduce the regression of cervical tumors, improve the rate of success of operation and prolong the survival time.