中文摘要：

MicroRNAs (miRNAs ) 是包括癌症，心疾病，神经病学的混乱，脉管的畸形和自体免疫的条件涉及众多的疾病的基因管理者。尽管 hsa-mir-499 rs3746444 多型性被显示贡献多重基因的危险性到癌症，数据让步了冲突结果。因此，这元分析被执行提供对在 hsa-mir-499 rs3746444 多型性和癌症风险之间的潜在的协会的一个全面评价。在这元分析，关于 10 合格盒子控制的 9 篇文章的一个总数用英语学习(包括 6134 个盒子和 7141 控制) 被分析。在 hsa-mir-499 rs3746444 多型性和全面癌症风险之间的重要协会都没被表明。然而，增加的风险在乳癌病人的亚群被观察(G 等位基因对 A 等位基因：或 = 1.10， 95% CI = 1.00-1.20；Pheterogeneity = 0.114；I2 =53.9%) 并且基于人口的研究(G 等位基因对 A 等位基因：或 = 1.12， 95% CI = 1.00-1.25；Pheterogeneity = 0.062；I2 =64.0%) 。调查结果建议了在 hsa-mir-499 rs3746444 多型性之间的一个协会并且增加了风险到乳癌。

英文摘要：

MicroRNAs（miRNAs） are gene regulators involved in numerous diseases including cancer,heart disease,neurological disorders,vascular abnormalities and autoimmune conditions.Although hsa-mir-499 rs3746444 polymorphism was shown to contribute to the susceptibility of multiple genes to cancer,the data have yielded conflicting results.Therefore,this meta-analysis was performed to provide a comprehensive assessment of potential association between hsa-mir-499 rs3746444 polymorphism and cancer risk.In this meta-analysis,a total of 9 articles regarding 10 eligible case-control studies in English（including 6134 cases and 7141 controls） were analyzed.No significant association between hsa-mir-499 rs3746444 polymorphism and overall cancer risk was demonstrated.However,an increased risk was observed in the subgroup of breast cancer patients（G allele vs A allele：OR = 1.10,95% CI = 1.00-1.20;P heterogeneity = 0.114;I 2 = 53.9%） and population-based studies（G allele vs A allele：OR = 1.12,95% CI = 1.00-1.25;P heterogeneity = 0.062;I 2 = 64.0%）.The findings suggested an association between hsa-mir-499 rs3746444 polymorphism and increased risk to breast cancer.