Asymmetric intramolecular oxa-Michael addition of activated α,β-unsaturated ketones by chiral N-triflyl phosphoramide
- ISSN号:0251-0790
- 期刊名称:《高等学校化学学报》
- 时间:0
- 分类:O621.254.1[理学—有机化学;理学—化学] TQ323.42[化学工程—合成树脂塑料工业]
- 作者机构:[1]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
- 相关基金:This work was supported by the National Natural Science Foundation of China (20732006 and 20821002).
关键词:
迈克尔, 分子氧, 不对称, 不饱和, 黄酮, 活性, 手性, 膦, asymmetric catalysis, Michael addition, chiral BrФnsted acids, N-triflyl phosphoramide, flavanone, enantioselectivity
中文摘要:
由 chiral N-triflyl phosphoramide 的激活的、不饱和的酉同类的不对称的 intramolecular oxa-Michael 增加被认识到。黄烷酮产品能与优秀收益(50%95%) 和多达 74% ee 被综合。
英文摘要:
Asymmetric intramolecular oxa-Michael addition of activated α,β-unsaturated ketones by chiral N-triflyl phosphoramide was realized. The flavanone products can be synthesized with excellent yields (50%-95%) and up to 74% ee.