中文摘要：

目的对Lewis大鼠肾阳虚体质及其HPA轴功能进行研究。方法采用氢化可的松皮下注射法和切除肾上腺损伤HPA法建立大鼠肾阳虚模型,同时Lewis大鼠与两种实验性肾阳虚模型进行比较,并用一般体征、行为学、神经内分泌功能等检测和方法评估Lewis大鼠肾阳虚程度。结果与正常Wistar大鼠比较,Lewis大鼠体重明显重于同周龄的Wistar大鼠,但体温、尿量和抓力明显低于Wistar大鼠（P〈0.01）,Lewis大鼠的记忆能力有下降趋势,Lewis大鼠肝脏指数、肾脏指数和肾上腺指数明显降低（P〈0.01）,血清促肾上腺皮质激素（ACTH）、促肾上腺皮质释放激素（CRH）、环磷酸鸟苷（cGMP）、皮质醇（Cort）和尿17-羟皮质类固醇（17OHCS）明显降低（P〈0.01）。结论因基因遗传而致Lewis大鼠肾上腺皮质功能减退,Lewis大鼠具有先天性肾阳虚体质-临界性肾阳虚证或肾阳虚证前期。

英文摘要：

Objective To investigate the kidney yang deficiency constitution and hypothalamus-pituitary-adrenal（ HPA） axis dysfunction in Lewis rats. Method Two kidney yang deficiency models were established by subcutaneous injection of hydrocortisone and by adrenalectomy to induce hypothalamic-pituitary-adrenal（ HPA） axis dysfunction in Lewis rats. Wistar rats were used as control and compared with the two types of Lewis rat models of kidney yang deficiency. The degree of kidney yang deficiency of the Lewis rats was evaluated by examination and detection of the general signs,behavior,and neuroendocrine function,and so on. Result Compared with the normal Wistar rats,the body weight of Lewis rats was significantly higher than that of Wistar rats at the same age. The body temperature,urine volume and grip strength were significantly lower than those of Wistar rats（ P〈0. 01 for all）. The memory ability of the Lewis rats was slightly decreased. The liver,kidney and adrenal indexes were significantly decreased in the Lewis rats（ P〈0. 01）. Thelevels of serum ACTH,CRH,cGMP,Cort and urine 17 OHCS were significantly decreased（ P〈0. 01）. Conclusion A very slight deficiency of adrenal cortex function of Lewis rats is caused by genetic inheritance,and Lewis rats have the constitution of congenital kidney yang deficiency（ criticality or prophase of kidney yang deficiency）.