中文摘要：

蓖麻毒素是植物来源的核糖体失活蛋白。蓖麻毒素必须通过细胞的内膜系统到达内质网，然后转位至胞质，才能作用于胞质内的核糖体。在内质网中毒素的两条链分离，具有催化活性的A链被内质网上的蛋白质识别，并被转位到胞质内催化核糖体失活。现对内质网在参与蓖麻毒素胞内转运过程中的作用进行综述。

英文摘要：

Ricin is a plant-derived ribosome inactivating protein. To target ribosomes in the mammalian cytosol, ricin must firstly retrograde transport to the endomembrane system of the cell to reach the endoplasmic reticulum. Here, the toxin is reduced and the catalytic A chain is recognised by endoplasmic reticulum components that facilitate its membrane translocation to the cytosol. This review summarises current understanding of these events.