中文摘要：

JAK/STAT信号转导通路的异常激活在多种淋巴瘤的发生发展中发挥重要作用. 该信号通路的抑制剂在淋巴瘤的靶向治疗中具有良好的应用前景．本文对JAK/STAT信号通路与淋巴瘤发生、发展的最新研究进展进行综述，重点介绍该信号通路中各种JAK激酶及STAT分子的异常突变类型，以及它们在各类淋巴瘤形成中的作用、调控机制及其靶向治疗策略，旨在为该信号通路在淋巴瘤发生发展中的影响及作用机制的进一步研究提供借鉴．

英文摘要：

The activation of Janus kinase（JAK）/signal transducer and activator transcription（STAT） pathway, which plays an important role in tumorigenesis, is aberrantly in a variety of lymphomas. Recently, the JAK/STAT inhibitors are being considered for their potentials in the therapy for lymphoma. This review summarizes the progresses on the JAK/STAT signaling pathway in the pathogenesis of lymphoma development. The genomic alterations and the mutations of JAK kinase and STATs in different lymphoma subtypes are outlined. The effects of disregulated JAK/STAT signaling and the regulatory mechanisms in lymphomagenesis are discussed. The application of JAK/STAT inhibitors as a potential therapeutic approach for lymphoma treatment is prospected.